{"text_format":"1","workbook":"xlsx","n_sheets":4,"sheets":["Calculator","Descriptors","References","Disclaimer"],"not_rendered":{"charts":0,"images":2,"macros":1,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Calculator","index":0,"n_rows":43,"n_cols":13,"rows_kept":43,"cut":false,"hidden":false,"merged":[]}
[null,"HCC Staging Calculator"]
[]
[null,0,null,null,"<34",">35","<1.7","None","None","No",1,"Yes","Yes"]
[null,1,null,null,"34-50","28-35","1.7-2.3","Controlled","Grade I-II","Yes",2,"No","No"]
[null,2,null,null,">50","<28",">2.3","Refractory","Grade III-IV",null,3,null,"N/A"]
[null,3,null,null,null,null,null,null,null,null,">3"]
[null,4]
[]
[]
[null,"Patient Characteristics:"]
[null,"Performance","Sodium","Creatinine","Total Bilirubin","Albumin","INR","Ascites","Hepatic"]
[null,"Status","(mmol/L)","(µmol/ L)","(µmol/ L)","(g/L)",null,null,"Encephalopathy"]
[null,{"$f":"B15","v":0},{"$f":"C15","v":0},{"$f":"D15","v":0},{"$f":"IF(E15<34,E3,IF(E15>50,E5,E4))","v":"<34"},{"$f":"IF(F15>35,F3,IF(F15<28,F5,F4))","v":"<28"},{"$f":"IF(G15<1.7,G3,IF(G15>2.3,G5,G4))","v":"<1.7"},{"$f":"H15","v":0},0]
[]
[]
[null,"Tumour Characteristics:"]
[null,"Portal","Number of","Are all nodules","If single nodule,"]
[null,"Invasion","Nodules","< 3cm?","is it < 2cm?"]
[null,{"$f":"B21","v":0},{"$f":"C21","v":0},{"$f":"D21","v":0},{"$f":"E21","v":0}]
[]
[]
[null,"TNM Clinical Classification:"]
[null,"T - Primary","N - Regional","M - Distant"]
[null,"Tumour","Lymph Nodes","Metastasis"]
[]
[null,"TX","NX","M0",null,"IA"]
[null,"T0","N0","M1",null,"IB"]
[null,"T1a","N1",null,null,"II"]
[null,"T1b",null,null,null,"IIIA"]
[null,"T2",null,null,null,"IIIB"]
[null,"T3",null,null,null,"IVA"]
[null,"T4",null,null,null,"IVB"]
[]
[]
[null,"Child-Pugh","Child-Pugh","BCLC","UKELD","Stage "]
[null,"Score","Stage","Stage"]
[null,{"$f":"IF(E13=E5,3,IF(E13=E4,2,IF(E13=E3,1,0)))+IF(F13=F5,3,IF(F13=F4,2,IF(F13=F3,1,0)))+IF(G13=G5,3,IF(G13=G4,2,IF(G13=G3,1,0)))+IF(H13=H5,3,IF(H13=H4,2,IF(H13=H3,1,0)))+IF(I13=I5,3,IF(I13=I4,2,IF(I13=I3,1,0)))","v":5},{"$f":"IF(B37<7,\"A\",IF(B37>9,\"C\",\"B\"))","v":"A"},{"$f":"IF(B13>2,\"D\",IF(C37=\"C\",\"D\",IF(B19=\"Yes\",\"C\",IF(B13=0,IF(C19=1,IF(E19=\"Yes\",IF(C37=\"A\",\"0\",\"A\"),IF(F19=\"Yes\",\"A\",\"B\")),IF(C19=\">3\",\"B\",IF(D19=\"Yes\",\"A\",\"B\"))),\"C\"))))","v":"B"},{"$f":"E39","v":{"$error":"#NUM!"}}]
[]
[null,{"$f":"IF(E13=E5,3,IF(E13=E4,2,IF(E13=E3,1,0)))+IF(F13=F5,3,IF(F13=F4,2,IF(F13=F3,1,0)))+IF(G13=G5,3,IF(G13=G4,2,IF(G13=G3,1,0)))+IF(H13=H5,3,IF(H13=H4,2,IF(H13=H3,1,0)))+IF(I13=I5,3,IF(I13=I4,2,IF(I13=I3,1,0)))+IF(E15=0,\"#\",IF(F15=0,\"#\",IF(G15=0,\"#\",IF(H15=0,\"#\",IF(I15=0,\"#\",0)))))","v":{"$error":"#VALUE!"}},{"$f":"IF(B39=\"#VALUE!\", \"#VALUE!\",IF(B37<7,\"A\",IF(B37>9,\"C\",\"B\")))","v":{"$error":"#VALUE!"}},{"$f":"IF(C39=\"#VALUE!\",\"#VALUE!\",IF(D41=0,IF(B13>2,\"D\",IF(C37=\"C\",\"D\",IF(B19=\"Yes\",\"C\",IF(B13=0,IF(C19=1,IF(E19=\"Yes\",IF(C37=\"A\",\"0\",\"A\"),\"A\"),IF(C19=\">3\",\"B\",IF(D19=\"Yes\",\"A\",\"B\"))),\"C\")))),\"#VALUE!\"))","v":{"$error":"#VALUE!"}},{"$f":" (5.395*LN(G15))+(1.485*LN(D15))+(3.13*LN(E15))-(81.565*LN(C15))+435","v":{"$error":"#NUM!"}},{"$f":"IF(D25=D27,F32,IF(C25=C28,F31,IF(B25=B32,F30,IF(B25=B31,F29,IF(B25=B30,F28,IF(B25=B29,F27,IF(B25=B28,F26,\"Unstaged\")))))))","v":"Unstaged"}]
[]
[null,null,null,{"$f":"IF(B21=0,\"#\",IF(C21=0,\"#\",IF(D21=0,\"#\",IF(E21=0,\"#\",0))))","v":"#"}]
[]
[null,"Developed by Dr Robert Driver & Dr Ian Rowe (Leeds Teaching Hospitals & University of Leeds) on behalf of the HCC-UK/ NCRAS Partnership"]

{"sheet":"Descriptors","index":1,"n_rows":94,"n_cols":5,"rows_kept":94,"cut":false,"hidden":false,"merged":[]}
[null,"BCLC Stage Descriptor:"]
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[null,"UKELD Score Formula:"]
[]
[null,"[(5.395 × ln(INR)) + (1.485 × ln(creatinine)) + (3.13 × ln(bilirubin)) − (81.565 × ln(Na))] + 435"]
[]
[null,"Child Pugh Score:"]
[]
[null,"Measure","1 Point","2 Points","3 Points"]
[null,"Total bilirubin, μmol/L","<34","34–50",">50"]
[null,"Serum albumin, g/L",">35","28–35","<28"]
[null,"INR","<1.7","1.7-2.3",">2.3"]
[null,"Ascites","None","Mild to Moderate","Severe or Refractory"]
[null,"Hepatic encephalopathy","None","Grade I–II","Grade III–IV"]
[]
[null,"Points","Class"]
[null,"5-6","A"]
[null,"7-9","B"]
[null,"10-15","C"]
[]
[null,"Ascites Grade:"]
[null,"Grade 1:","mild ascites only detectable by ultrasound examination"]
[null,"Grade 2","moderate symmetrical distension of abdomen"]
[null,"Grade 3:","large or gross ascites with marked abdominal distension"]
[null,"Refractory:","recurrence cannot be satisfactorily prevented by medical therapy"]
[]
[null,"Encephalopathy Grade:"]
[]
[null,"Grade 1 - Trivial lack of awareness; euphoria or anxiety; shortened attention span; impaired mentation"]
[null,"Grade 2 - Lethargy or apathy; minimal disorientation for time or place; subtle personality change; inappropriate behaviour"]
[null,"Grade 3 - Somnolence to semistupor, but responsive to verbal stimuli; confusion; gross disorientation"]
[null,"Grade 4 - Coma"]
[]
[null,"ECOG Performance Status:"]
[]
[null,0,"Fully active, able to carry on all pre-disease performance without restriction"]
[null,1,"Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work"]
[null,2,"Ambulatory and capable of all selfcare but unable to carry out any work activities; up and about more than 50% of waking hours"]
[null,3,"Capable of only limited selfcare; confined to bed or chair more than 50% of waking hours"]
[null,4,"Completely disabled; cannot carry on any selfcare; totally confined to bed or chair"]
[]
[null,"TNM Classification:"]
[]
[null,"Stage Group","T stage","N stage","M stage"]
[null,"Stage IA","T1a","N0","M0"]
[null,"Stage IB","T1b","N0","M0"]
[null,"Stage II","T2","N0","M0"]
[null,"Stage IIIA","T3","N0","M0"]
[null,"Stage IIIB","T4","N0","M0"]
[null,"Stage IVA","Any T","N1","M0"]
[null,"Stage IVB","Any T","Any N","M1"]
[]
[null,"TNM Clinical Classification"]
[null,"T – Primary Tumour"]
[null,"TX","Primary tumour cannot be assessed"]
[null,"T0","No evidence of primary tumour"]
[null,"T1a","Solitary tumour 2 cm or less in greatest dimension with or without vascular invasion"]
[null,"T1b","Solitary tumour more than 2 cm in greatest dimension without vascular invasion"]
[null,"T2","Solitary tumour with vascular invasion more than 2 cm dimension or multiple tumours, none more than 5 cm in greatest dimension"]
[null,"T3","Multiple tumours any more than 5 cm in greatest dimension"]
[null,"T4","Tumour(s) involving a major branch of the portal or hepatic vein with direct invasion of adjacent organs (including the diaphragm), other than the gallbladder or with perforation of visceral peritoneum"]
[null,"N – Regional Lymph Nodes"]
[null,"NX","Regional lymph nodes cannot be assessed"]
[null,"N0","No regional lymph node metastasis"]
[null,"N1","Regional lymph node metastasis"]
[null,"M – Distant Metastasis"]
[null,"M0","No distant metastasis"]
[null,"M1","Distant metastasis - This includes metastasis to non-regional lymph nodes, including periaortic, pericaval, superior mesenteric artery and/or coeliac artery lymph nodes."]

{"sheet":"References","index":2,"n_rows":14,"n_cols":1,"rows_kept":14,"cut":false,"hidden":false,"merged":[]}
["BCLC Stage:"]
["EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. 2012. J Hepatol, 56, 908-43."]
["UKELD Score:"]
["CHOLONGITAS, E., GERMANI, G. & BURROUGHS, A. K. 2010. Prioritization for liver transplantation. Nat Rev Gastroenterol Hepatol, 7, 659-68."]
["Child Pugh Score:"]
["PUGH, R. N., MURRAY-LYON, I. M., DAWSON, J. L., PIETRONI, M. C. & WILLIAMS, R. 1973. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg, 60, 646-9."]
["Ascites Grade:"]
["MOORE, K. P., WONG, F., GINES, P., BERNARDI, M., OCHS, A., SALERNO, F., ANGELI, P., PORAYKO, M., MOREAU, R., GARCIA-TSAO, G., JIMENEZ, W., PLANAS, R. & ARROYO, V. 2003. The management of ascites in cirrhosis: report on the consensus conference of the International Ascites Club. Hepatology, 38, 258-66."]
["Encephalopathy Grade:"]
["VILSTRUP, H., AMODIO, P., BAJAJ, J., CORDOBA, J., FERENCI, P., MULLEN, K. D., WEISSENBORN, K. & WONG, P. 2014. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology, 60, 715-35."]
["ECOG Performance Status:"]
["OKEN, M. M., CREECH, R. H., TORMEY, D. C., HORTON, J., DAVIS, T. E., MCFADDEN, E. T. & CARBONE, P. P. 1982. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol, 5, 649-55."]
["TNM Clinical Classification:"]
["Union for International Cancer Control: TNM Classification of Malignant Tumours, 8th Edition. [Available from: http://www.hoofdhalskanker.info/wpavl/wp-content/uploads/TNM-Classification-of-Malignant-Tumours-8th-edition.pdf]"]

{"sheet":"Disclaimer","index":3,"n_rows":8,"n_cols":1,"rows_kept":8,"cut":false,"hidden":false,"merged":[]}
["This calculator has been developed by Dr Robert Driver and Dr Ian Rowe (Leeds Teaching Hospitals and University of Leeds) on behalf of the HCC-UK/ NCRAS Partnership."]
[]
["Calculations are based on published formulae contained within the Descriptors and References tabs. "]
[]
["This calculator is for the purpose of data collection for the Hepatocellular Carcinoma (HCC) Cancer Outcomes and Services Dataset (COSD). Enquiries should be directed to Dr Anya Burton [anya.burton@phe.gov.uk]."]
["It does not replace clinical assessment and clinical, radiological and histopathological staging of HCC and the Cancer Multidisciplinary Team for management decisions."]
["This UKELD calculator should not be used in place of the NHS Organ Donation and Transplantation (ODT) UKELD Calculator for the purposes of listing for liver transplantation."]
["The ODT UKELD calculator is available via: https://www.odt.nhs.uk/transplantation/tools-policies-and-guidance/calculators/"]